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Introduction to Macromolecular Crystallography


  • Author: Alexander McPherson.
  • Publisher: John Wiley & Sons, Inc.
  • ISBN: 0-471-25122-4.


List of Chapters: An Overview of Macromolecular Crystallography | The Nature of Crystals: Symmetry and the Unit Cell | Waves and Their Properties | Diffraction from Points, Planes, Molecules and Crystals | Examination of Diffraction and Bragg's Law | Solving the Phase Problem | Interpreting Patterson Maps | Electron Density Maps and Difference Fourier Maps.

Crystallography has become the keystone of rational pharmacology, protein engineering, structural genomics, proteomics, bioinformatics, and nanotechnology. By growing molecules in three-dimensional crystal forms, researchers can determine precise molecular structure, leading to major advances in biotechnology applications such as improved drugs and crops. Introduction to Macromolecular Crystallography provides a comprehensive, approachable summary of the field of crystallography, from the fundamental theory of diffraction and properties of crystals to applications in determining macromolecular structure. Dedicated to providing a complete introduction to the subject that does not assume a background in physics or math, the book's contents flow logically from basic principles to key methods, such as those for solving phase problems, interpretation of Patterson maps, and the difference Fourier method. The Introduction includes practical instruction on the interpretation of data and methods for determining phases and also:

  • Illustrates concepts throughout to clarify difficult ideas
  • Integrates analogies to illuminate the text
  • Presents a non-technical, approachable style, ideal for biologists, biochemists, and students
  • Equips the reader to employ the range of programs in crystallography

Biochemists, molecular biologists, and pharmacological scientists, as well as advanced undergraduate and graduate students in molecular and cell biology, biochemistry, and biophysics, will find Introduction to Macromolecular Crystallography an invaluable introduction to this pivotal field.

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