I have been working in the lab since April of 2006. Some of my work focuses around maintaining laboratory functions.
Work has also begun on tubule purification and hopeful visiualization. I have collected datasets of tilt series from sonic muscle fibres, aligned them,
and am currently trying to pick regions of interest so we can further analyse them. And finally I am keeping up this website.
PUBLICATIONS
Wolfe, C.L., Warrington, J.A., Treadwell, L., and Norcum, M.T. A Three-Dimensional Working Model of the Multisynthetase Complex based on Placements of tRNA and Proteins using Computational Microscopy. J. Biol. Chem., submitted March 2005.
Norcum, M.T., Warrington, J.A., Spiering, M., Ishmael, F.T., Trakselis, M.A., and Benkovic, S.J. 2005. Architecture of the Bacteriophage T4 Primosome: Electron Microscopy Studies of Helicase (gp41) and Primase (gp61). Proc. Natl. Acad. Sci.10: 3623-3626.
Wolfe, C.L., Warrington, J.A., Davis, S., Green, S., and Norcum, M.T. 2003. Isolation and Characterization of Human Nuclear and Cytosolic Multisynthetase Complexes and the Intracellular Distribution of p43/EMAPII. Prot. Sci.12: 2282-2290.
Norcum, M.T. and Warrington, J.A. 2000. The cytokine portion of p43 occupies a central position within the eukaryotic multisynthetase complex. J Biol Chem Accelerated Publication275:17921-17924.
Norcum, M.T. and Warrington, J.A. 1998. Structural analysis of the multienzyme amino-acyl tRNA synthetase complex: a three domain model based on reversable crosslinking. Prot. Sci.7: 79-87.
Jiang, S., Wolfe, C.L., Warrington, J.A., Norcum, M.T. Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit. FEBS Lett. 2005 Nov 7;579:6049-54.
