R-free2005 Distribution

Downloading the software

• Description: A software package that allows the user to calculate less bias R-free for cases with Non Crystallographic Symmetry, by deleting the neighboring reflections of test set based on G-function. Implemented as a module to the refinement program CNS. This software is described in detail in Fabiola et al., "Bias in Cross-validated Free R-factors: Mitigation of the effects of Non-Crystallographic Symmetry".
• License agreement: A Word Document File of a license agreement that may be printed locally and returned to initiate distribution, or digitally signed and returned by e-mail. Rfree2005 is distributed at no cost over the internet to not-for-profit academic institutions. A license agreement can be downloaded, signed and returned for a password to download the programs. Licenses with commercial entities are agreed on a case-by-case basis. Pending execution of a permanent license agreement, users at for-profit institutions can request temporary permission to evaluate the program by sending e-mail to the authors.
• Distribution: For WWW distribution, licensed users will be provided with a password so that they can copy a compressed tar file. Before clicking on Rfree2005.tar.gz be sure to set the Options of your WWW browser to Load to local disk and save the file in the parent directory where Rfree2005 is to be installed. The package can then be installed with the commands gunzip Rfree2005.tar.gz; tar xvpf Rfree2005.tar. Further details are given in the README file.