Sponsored by: Agouron Pharmaceuticals, Inc., Bruker AXS;
Emerald Biostructures, Inc., F. Hoffmann-La Roche, Inc.; Florida State
University; Glaxo Smith Kline; Gordon Research Conferences; Hampton Research
Corp.; IMCAT; MAR USA Inc.; Merck & Co., Inc.; Molecular Structure Corp.;
National Institutes of Health; Pharmacia & Upjohn, Inc.; Structural
Genomix.
Last
updated 7/11/02.
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Sunday 14th
July |
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Arrival & check-in |
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Dinner |
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Membrane Proteins + Don Wiley Memorial |
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Discussion leader: Cynthia
Stauffacher ( |
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Patrick Loll ( Crystallization
Screens for Membrane Proteins – Can we Achieve Reasonable Success Rates? |
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TBA or
Cynthia Stauffacher ( Title |
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Introduction – to Wiley Memorial Lecture Steve
Harrison
( |
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Ian Wilson (The
Scripps Research Institute) Don
Wiley Memorial Lecture: Structural Basis of Cellular Immune Recognition |
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Monday 15th
July |
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Breakfast |
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Data Collection: Automation & Phasing requirements |
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Discussion leader: B.-C.
Wang ( |
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B.-C. Wang ( Automation
in Protein Crystallography Data Collection - An Overview |
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Zheng-Qing
Fu
( Approaching
Automation Of Data Acquisition: Quality Control
and Evaluation |
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Steve
Muchmore
(Abbott Laboratories Inc.) Robotics
101: A field guide to crystal
mounting and data collection robotics |
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Howard
Robinson
(Brookhaven National Laboratory) Remote
Synchrotron Crystallography: FedEx
Web Tools & Databases |
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Coffee Break |
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New Approaches to the
Phase Problem |
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Discussion Leader: Wayne
Hendrickson ( |
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B.-C. Wang ( Direct
Crystallography: Phasing From Native |
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Randy Read ( New
Advances in Maximum Likelihood Phasing |
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Photograph! |
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Lunch |
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Free time |
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Poster
session |
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Dinner |
Evening session
continues…
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Monday 15th
July, continued |
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New Approaches to
the Phase Problem (continued) |
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Discussion Leader: Wayne
Hendrickson ( |
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Gerard
Bricogne
(Global Phasing, Ltd.) Bayesian
approaches to exploiting weak phasing signals |
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Tom
Terwilliger ( Maximum-likelihood
Density Modification and Automated Model-building |
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Victor
Lamzin (European
Molecular Biology Organization) ARP/wARP
for |
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Wayne
Hendrickson ( Options
in MAD Phasing |
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Tuesday 16th
July |
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Breakfast |
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Ribosomes &
Large Complexes |
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Discussion Leader: Jennifer
Doudna ( |
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Venki
Ramakrishnan (MRC / Some
General Lessons from the Determination of the Structure of the 30S Ribosomal
Subunit |
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The
High Resolution Structures of the Two Ribosomal Subunits: Functional Insights |
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Roger
Burnett
(Wistar Institute / Combined
Imaging with X-ray Crystallography and Electron Microscopy Reveals the Shared
Evolving Architecture of Human Adenovirus and the Lipid-Containing
Bacteriophage PRD1 |
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Coffee Break |
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Jamie Cate ( Structural
studies of the bacterial ribosome |
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Undeterred –
Impressive structure determinations 2
or 3 favorite posters of Profs. Doudna, Stauffacher & Hendrickson |
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Tom Steitz ( The
atomic structure of the ribosome: how we got there and what we learned |
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Lunch |
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Free time |
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Poster
session |
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Dinner |
Evening session
continues…
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Tuesday 16th
July, continued |
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Enzyme Mechanism |
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Discussion Leader: Greg
Petsko ( |
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Dagmar Ringe ( Structural
Enzymology of Pyridoxal Phosphate Dependent Enzymes |
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TBA Title |
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Hot posters
in Mechanism, Structure Analysis… 2 of the best Introduced by Greg
Petsko and David Eisenberg |
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Karen Allen ( Caught
in the Act: Enzyme Transition States and Intermediates |
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Wednesday 17th
July |
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Breakfast |
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New Detector
Technologies |
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Discussion Leaders: Andy
Howard (Illinois Institute of Technology) |
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Andy Howard (Illinois
Institute of Technology) New
Crystallographic Detector Technologies: Ready for Prime Time |
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Roger Durst (Bruker /
Nonius Inc.) Advances
in CCD Technology for X-Ray Crystallography |
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Klaus
Bartels
(MAR Research) Minimizing
the point-spread function: flat panel detectors |
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Coffee Break |
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More Than Intuition
– Theoretical Analysis of Structure in Understanding Function |
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Discussion Leader: Alex
MacKerrel ( |
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Alex
MacKerrel
( Computational
Studies of Base Flipping In DNA Alone
and Complexed to the Cytosine 5-Methyltransferase from HhaI |
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Jeff
Evanseck
( Mapping
Biomechanical Motion by Chemometric Methods |
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Jiali Gao ( Dynamics,
Pathways and Tunneling in Enzyme Catalysis: A Computational Perspective |
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Michael
Gilson
(Center for Advanced Research in Biotechnology) Understanding
Molecular Interactions |
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Lunch |
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Free time |
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Poster
session |
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Dinner |
Evening session
continues…
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Wednesday 17th
July, continued |
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Structure
Visualization & Analysis |
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Discussion Leader: Art
Olson (The Scripps Research Institute) |
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Art Olson (The Scripps
Research Institute) Tangible
Interfaces for Molecular Biology |
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Joe Corkery (Open Eye
Software Inc.) Visualization
and Data Analysis with VIDA |
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Michel
Sanner
(The Scripps Research Institute) Component-based
Molecular Visualization |
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Chandrajit
Bajaj
( Analysis
and Visualization of Electron Density and Other Volumetric Macromolecular
Properties |
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Thursday 18th
July |
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Breakfast |
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Integrating Sequence
& Structural Analysis |
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Discussion Leader: David
Eisenberg ( |
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Janet
Thornton
(Eur. Bioinformatics Inst. & Univ. Coll., From
Protein Structure to Biological Function and Evolution |
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Ed Marcotte ( Global
organization of proteins into pathways and systems |
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Poster
mini-talks (selected by Alex MaxKerrel & Art Olson) Models
of Analysis & Interpretation… |
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Coffee Break |
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Andrej Sali ( Modeling
of the Structure of Proteins and Macromolecular Assemblies |
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David
Eisenberg
( Protein
Interactions: Amyloids and Prions |
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Business meeting |
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Lunch |
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Free time |
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Poster
session |
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Dinner |
Evening session
continues…
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Thursday 18th
July, continued |
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What’s New in
Averaging – |
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Discussion Leader: Art
Olson (The Scripps Research Institute) |
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Art Olson (The
Scripps Research Institute) Opening
comments |
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Gerard
Bricogne
(Global Phasing, Ltd.) Averaging
in the old days |
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Jack Johnson (The
Scripps Research Institute) Combining
cryoEM and crystallography; strategies and results |
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Steve
Harrison
( Complex
Virus Structures |
FRIDAY 19th July |
7:30
am - 8:30 pm Breakfast
9:00
am Departure
GENERAL NOTES:
Most
talks are 30 minutes, including 5 minutes of discussion. In a few cases it has been possible to
extend them to 35 minutes, in which the last 10 minutes should be reserved for
discussion.
Last
updated: Thursday, July 11, 2002