Timothy Logan | Homepage

Associate Professor of Chemistry & Biochemistry

Research Interests

My major research interests focus on the connection between protein structure and protein function. My research training is in multidimensional biomolecular NMR spectroscopy but we also use other spectroscopies and biophysical techniques as necessary to solve our research problems. To learn more about my research projects, follow the Research links on this page.

Over one half of the proteins in the human genome are anticipated to be glycosylated at one or more sites, making glycosylation the most prevalent, by far, post-translational modification. Depite the wealth of biological data demonstrating the biological significance of glycosylation, three dimensional analysis of intact glycoproteins lags far behind that of non-glycosylated proteins. The major challenge facing strutural glycobiologists is the inherent heterogeneity in cabohydrate patterns found even within singly glycosylated glycoproteins.We have successfully addressed the glycoform heterogeneity problem by expressing recombinant proteins in Chinese hamster ovary cells that carry mutations in specific glycosyltransferases.

Teaching

BCH 4053: General Biochemistry 1

This is the first course in a two-semester sequence that covers the fundamentals of biochemistry. The course is targeted for advanced undergraduate and beginning graduate students in chemistry, biology, and engineering. The course objective is to establish and identify the chemical principles that govern biological processes. Topics covered include Bioenergetics, Structural Biology, Membrane Biology, and Catabolic Metabolism.